Back to top









Recent update (Jul. 14, 2023)

Targeted Protein Upregulation of STING for Boosting the Efficacy of Immunotherapy. Cho, W.†; Won, S.†; Choi, Y.; Yi, S; Park, J.B.; Park, J.-G.; Kim, C.E.; Narayana, C.; Kim, J.H., Yim, J. Choi, Y. I. Lee, D.-S.*; Park, S.B.*;  Angew. Chem. Int. Ed. 2023, e202300978. (DOI: 10.1002/anie.202300978) (IF: 16.823)

Inhibition of ACE2-Spike interaction by ACE2 allosteric binder suppresses SARS-CoV-2 entry. Shin, Y.-H.†; Jung, K.†; Lee, J.; Lee, H.J.; Kim, J.; Kim, S.*; Park, S. B.*;  Angew. Chem. Int. Ed. 2022, 61, e202115695. (DOI: 10.1002/anie.202115695) (IF: 16.823)

Host immunomodulatory lipids created by symbionts from dietary amino acids. Oh, S.F.†*; Praveena, T.†; Song, H.B.; Yoo, J.-S.; Jung, D.-J; Erturk-Hasdemir, D.; Hwang, Y.S.; Lee, C.C.; Nours, J.L.; Kim, H.; Lee, J.; Blumberg, R.S.; Rossjohn, J.*; Park, S.B.*; Kasper, D.L.*  Nature 2021, 600, 302–307. (DOI: 10.1038/s41586-021-04083-0) (†: equally contributed) (IF: 69.504)

Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling. Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S. B.* Angew. Chem. Int. Ed. 2021, 60, 1831–1838. (Cover article) (IF=12.959)

Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for the late-stage conjugation of vitamin B3 to (hetero)arylamine therapeutics. Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S. B.* Nature Communications 2020, 11, 6308. (†: equally contributed) (IF=12.121)

Label-free target identification reveals oxidative DNA damage as a mechanism of selective cytotoxic agent in cells with downregulated mismatch repair pathway. Park, H.; Park, S. B.* Chem. Sci. 2019, 10(12), 3449–3458. (IF=9.063)

Divergent Synthetic Pathway for Pyrimidine-Embedded Medium-Sized Azacycles through N-quaternizing Strategy. Choi, Y.†; Kim, H.†; Park, S. B.* Chem. Sci. 2019, 10(2), 569–575. (IF=9.063)

Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton. Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc. 2018, 140(3), 974-983. (Selected as Cover Article). (IF=13.858)

Label-Free Target Identification Using In-Gel Fluorescence Difference via Thermal Stability Shift. Park, H.; Ha, J.; Koo, J.Y.; Park, J.; Park, S.B.* Chem. Sci. 2017, 8(2), 1127-1133. (IF=9.144)

Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction. Kim, J.†; Jung, J.†; Koo, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7, 13196. (IF=11.329)

Discovery of small-molecule inhibitors of protein–microRNA interaction using a high-throughput binding assay with a site-specifically labeled Lin28. Lim, D.; Byun, W.G.; Koo, J.Y.; Park, H.; Park, S.B.* J. Am. Chem. Soc. 2016, 138, 13630-13638. (IF=13.038)

β-Turn Mimetic-based Stabilizers of Protein-Protein Interactions for the Study of the Non-canonical Roles of Leucyl-tRNA Synthetase. Kim, C.†; Jung, J.†; Tung, T.T.; Park, S.B.* Chem. Sci. 2016, 7, 2753-2761. (IF=9.211)

Rational Improvement of Molar Absorptivity Guided by Oscillator Strength: A Case Study with Furoindolizine-based Core Skeleton. Lee, Y.; Jo, A.;Park, S.B.* Angew. Chem. Int. Ed. 2015, 54(52),15689-15693. (IF: 11.336).

Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor. Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547. (IF: 24.348)

Members

Professor, Researchers, Students and Alumni

Professor

Recent update

Prof. Park's biography, personal activities and awards. Read More

Seung Bum Park

Researchers

Recent update

Information of Research Professor, Postdoctoral Fellows, Graduate Students, and Administrative Coordinator. To learn more about a lab member, please click on their photo.
Read More

Community

Notice and Gallery


apr. 21, 2023

Sciecne and technology medal of honor, Korean Government
2023 과학정보통신의날 기념
과학기술포장 수상

dec. 16, 2019

Reserach excellency award, Seoul National University
서울대학교 학술연구상 수상

dec. 06, 2013

new chembiolab webpage!!!
special thx to hot six...

 

 

 

Contact Us

Get in touch with chembiolab!