Papers
2003 - 2024
2003 - 2024
2024
(189) Unveiling the concealed reactivity of masked diformylmethane with RAHB-assisted enamines leads to dissymmetric di-meta-substituted pyridines. Yi, S.‡; Lee, J.H.‡; Cho, H.‡; Vaithegi, K.; Yi, D.; Noh, S.; Park, S.B.*Nat. Commun., submitted
(188) Broad-Spectrum Antiviral Agents against SARS-CoV-2 Variants by Inhibiting a Conserved Viral Protein, Nsp1-RNA Interaction. Byun, W.G.; Lee, M.; Ko, M.; Lee, J.H.; Yi, S.; Kim, S.; Park, S.B.*Angew. Chem. Int. Ed., In revision
(187) Inflachromene ameliorates Parkinson’s disease via targeting Nrf2-binding Keap1. Yim, J.; Hwang, Y.S.; Lee, J.-J.; Kim, J.H.; Baek, J.Y.; Jeong J.Y.; Choi, Y.; Jin, B.K.; Park, S.B.* Chem. Sci. 2024, 15, 3588-3595. (DOI: 10.1039/D3SC06997D) (IF:9.989)
2023
(186) Neuroinflammation-modulating agent SB1617 enhances autophagy-associated phagocytosis to mitigate tau pathology. Cho, H.; Choi, B.Y.; Shin, Y.-H.; Suh, S.W.; Park, S.B.* ACS Chem. Neurosci. 2023, 14, 4139-4152. (DOI: 10.1021/acschemneuro.3c00508) (IF:5.78)
(185) Ultrafluorogenic Monochromophore-type BODIPY-Tetrazine Series for Dual-color Bioorthogonal Imaging with a Single Probe. Kim, D.†; Son, H.†; Park, S.B.* Angew. Chem. Int. Ed. 2023, 62, e202310665. (DOI: 10.1002/anie.202310665) (with front cover) (IF: 16.82)
(184) STING upregulation strategies to potentiate STING immunotherapy. Cho, W.; Lee, J.H.; Park, S.B.* Future Med. Chem. 2023, 15(20), 1819-1822. (DOI: 10.4155/fmc-2023-0227) (invited editorial) (IF: 4.2)
(183) Synthesis of substituted pyridines with diverse functional groups via the remodeling of (Aza)indole/Benzofuran skeletons. Vaithegi, K.†; Yi, S.†; Lee, J.H.; Varun, B.V.; Park, S.B.* Commun. Chem. 2023, 6, 112. (DOI: 10.1038/s42004-023-00914-5) (IF: 7.211)
(182) Inflachromene attenuates seizure severity in mouse epilepsy models via anti-HMGB1 translocation. Dai, S.; Shao, Y.; Zhen, Y.; Sun, J.; Li, Z.; Shi, J.; Xu, C.; Cho. W.; Yi, S.; Park, S.B.; Wang, Y.*; Chen, Z.* Acta Pharmacologica Sinica 2023, 44, 1737-1747. (DOI: 10.1038/s41401-023-01087-6) (IF: 7.169)
(181) SB2301-mediated perturbation of membrane composition in lipid droplets induces lipophagy and lipid droplets ubiquitination. Jung, J.; Park, J.; Kim, M.; Ha, J.; Cho, H.; Park, S.B.* Commun. Biol. 2023, 6, 300. (DOI: 10.1038/s42003-023-04682-9) (IF: 6.268)
(180) Targeted Protein Upregulation of STING for Boosting the Efficacy of Immunotherapy. Cho, W.†; Won, S.†; Choi, Y.; Yi, S; Park, J.B.; Park, J.-G.; Kim, C.E.; Narayana, C.; Kim, J.H., Yim, J. Choi, Y. I. Lee, D.-S.*; Park, S.B.* Angew. Chem. Int. Ed. 2023, 62(18), e202300978. (DOI: 10.1002/anie.202300978) (Cover article) (IF: 16.823)
2022
(179) Chemistry revolutionizes genetics and epigenetics. Yoshida, M*; Park, S.B.* Curr. Opin. Chem. Biol. 2022, 72, 102247. (DOI: 10.1016/j.cbpa.2022.102247) (IF: 8.822)
(178) Phenotype-based screening rediscovered benzopyran-embedded microtubule inhibitors as anti-neuroinflammatory agents by modulating the tubulin-p65 interaction. Yim, J.; Lee, J.; Yi, S.; Koo, J.Y.; Oh, S.; Park, H.; Bae, M.A.; Park, J.*; Park, S.B.* Exp. Mol. Med. 2022, 54, 2200–2209. (DOI: 10.1038/s12276-022-00903-z) (IF: 12.153)
(177) Extended applications of small-molecule covalent inhibitors toward novel therapeutic targets. Lee, J.; Park, S.B.* Pharmaceuticals 2022, 15(12), 1478. (DOI: 10.3390/ph15121478) (IF: 5.215)
(176) Fluorophore labeling of proteins: a versatile trigger-release-conjugation platform based on the quinone methide chemistry. Jung, Y.; Sarkar, S.; Ha, J.; Park, S.B.; Ahn, K.H.* Bioconjugate Chem. 2022, 33(8), 1543–1551. (DOI: 10.1021/acs.bioconjchem.2c00297) (IF: 4.774)
(175) S-Benproperine, an active stereoisomer of benproperine, suppresses cancer migration and tumor metastasis by targeting ARPC2. Jang, H.-J.; Yoon, Y.J.; Choi, J.; Lee, Y.-J.; Lee, S.; Cho, W.; Byun, W.G.; Park, S.B.; Han, D.C.*; Kwon, B.-M.* Pharmaceuticals 2022, 15(12), 1462. (DOI: 10.3390/ph15121462) (IF: 5.215)
(174) Small-molecule modulators of protein-RNA interactions. Byun, W.G.†; Lim, D.†; Park, S.B.* Curr. Opin. Chem. Biol. 2022, 68, 102149. (DOI: 10.1016/j.cbpa.2022.102149) (invited review) (special issue: Chemical Genetics and Epigenetics) (IF: 8.822)
(173) Label-free target identification reveals the anti-cancer mechanism of a rhenium isonitrile complex. Yim, J.; Park, S.B.* Front. Chem. 2022, 10, 850638. (DOI: 10.3389/fchem.2022.850638) (IF: 5.221)
(172) Systematic exploration of furoindolizine-based molecular frameworks towards a versatile fluorescent platform. Lee, Y.†; Kim, D.†; Park, S.B.* Chem. Eur. J. 2022, 28, e202200533. (DOI: 10.1002/chem.202200533) (IF: 5.236)
(171) Design and synthesis of conformationally diverse pyrimidine-embedded medium/macro- and bridged cycles via skeletal transformation. Choi, Y.; Lee, S.; Kim, H.; Park, S.B.* Front. Chem. 2022, 10, 841250. (DOI: 10.3389/fchem.2022.841250) (IF: 5.221)
(170) Inhibition of ACE2-Spike interaction by an ACE2 binder suppresses SARS-CoV-2 entry. Shin, Y.-H.†; Jeong, K.†; Lee, J.; Lee, H.J.; Kim, J.; Kim, S.*; Park, S.B.* Angew. Chem. Int. Ed. 2022, 61, e202115695. (DOI: 10.1002/anie.202115695) (IF: 16.823)
2021
(169) Host immunomodulatory lipids created by symbionts from dietary amino acids. Oh, S.F.†*; Praveena, T.†; Song, H.B.; Yoo, J.-S.; Jung, D.-J; Erturk-Hasdemir, D.; Hwang, Y.S.; Lee, C.C.; Nours, J.L.; Kim, H.; Lee, J.; Blumberg, R.S.; Rossjohn, J.*; Park, S.B.*; Kasper, D.L.* Nature 2021, 600, 302–307. (DOI: 10.1038/s41586-021-04083-0) (†: equally contributed) (IF: 69.504)
(168) Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2. Byun, W.G.; Lee, J.; Kim, S.; Park, S.B.* Chem. Commun. 2021, 57, 12476–12479. (DOI: 10.1039/D1CC05508A) (IF: 5.996)
(167) Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion. Ha, J.; Park, S.B.* Commun. Biol. 2021, 4, 1123. (DOI: 0.1038/s42003-021-02643-8) (IF: 6.268)
(166) Recent advances in the development of covalent inhibitors. Kim, H.†; Hwang, Y.S.†; Kim, M; Park, S.B.* RSC Med. Chem. 2021, 12, 1037–1045. (DOI: 10.1039/D1MD00068C) (†: equally contributed) (IF:3.470)
(165) Phenotypic discovery of SB1501, an anti-obesity agent, through modulating mitochondrial activity. Jo. A.†; Kim, M.†; Ha, J.; Kim, J.-I.; Nam, H.; Hwang, I.; Kim, J.B.; Park, S.B.* ChemMedChem 2021, 16, 1104–1115. (DOI: 10.1002/cmdc.202100062) (†: equally contributed) (IF:3.124)
(164) Recent advances in identifying protein targets in drug discovery. Ha, J.†; Park, H.†; Park, J.*; Park, S.B.* Cell Chem. Biol. 2021, 28(3), 394–423. (DOI: 10.1016/j.chembiol.2020.12.001) (†: equally contributed) (IF=7.739)
(163) Phenotypic discovery of neuroprotective agents by regulation of Tau proteostasis via stress‐responsive activation of PERK signaling. Shin, Y.-H.; Cho, H.; Choi, B.Y.; Kim, J.; Ha, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed. 2021, 60, 1831–1838. (DOI: doi.org/10.1002/anie.202013915) (Cover article) (IF=16.823)
(162) The blockade of cytoplasmic HMGB1 modulates the autophagy/apoptosis checkpoint in stressed islet beta cells. Chung, H.†; Nam, H.†; Thuy, N.-P.; Jang, J.; Hong, S.J.; Choi, S.W.; Park, S.B.*; Park, C.-G.* Biochem. Biophy. Res. Commun. 2021, 534, 1053–1058. (DOI: 10.1016/j.bbrc.2020.10.038) (†: equally contributed) (IF=3.322)
2020
(161) Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines. Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nat. Commun. 2020, 11, 6308. (DOI: 10.1038/s41467-020-19610-2) (†: equally contributed) (IF=12.121)
(160) Phenotypic discovery of an antivirulence agent against Vibrio vulnificus via modulation of quorum-sensing regulator SmcR. Kim, S.M.†; Park, J.†; Kim, B.; Kim, M.S.; Song, H.; Park, H; Choi, S.H.*; Park, S.B.* ACS Infect. Dis. 2020, 6, 3076–3082. (DOI: 10.1021/acsinfecdis.0c00587) (†: equally contributed) (IF=4.960)
(159) Intravital longitudinal imaging of hepatic lipid droplet accumulation in a murine model for nonalcoholic fatty liver disease. Moon, J.; Kong, E.; Lee, J.; Jung, J.; Kim, E.; Park, S.B.; Kim, P.* Biomed. Opt. Express 2020, 11(9), 5132–5146. (DOI: 10.1364/BOE.395890) (IF:3.910)
(158) Two-photon and multicolor fluorogenic bioorthogonal probes based on tetrazine-conjugated naphthalene fluorophores. Kim, D.; Lee, J.-H.; Koo, J.Y.; Kim, H.M.; Park, S.B.* Bioconjugate Chem. 2020, 31(5), 1545–1550. (DOI: 10.1021/acs.bioconjchem.0c00197) (IF=4.349)
(157) Discovery of small-molecule modulators of protein-RNA interactions by fluorescence intensity-based binding assay. Byun W.G.; Lim, D.; Park, S.B.* ChemBioChem 2020, 21(6), 818–824. (DOI: 10.1002/cbic.201900467) (selected as Front Cover article) (IF: 2.593)
2019
(156) Development of azo-based turn-on chemical array system for hydrazine detection with fluorescence pattern analysis. Shin M.C.; Lee, Y.; Park, S.B.*; Kim, E.* ACS Omega 2019, 4(12), 14874–14885. (DOI: 10.1021/acsomega.9b01487) (IF=2.584)
(155) Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation. Jang, J.Y.†; Kim, H.†; Kim, H.-J.; Suh, S.W.; Park, S.B.*; Han, B.W.* Sci. Rep. 2019, 9, 11168. (DOI: 10.1038/s41598-019-47672-w) (†: equally contributed) (IF=4.011)
(154) Rational design and synthesis of reversible covalent PPARγ antagonistic ligands inhibiting Ser273 phosphorylation. Kim, H.; Jo, A.; Choi, S.-S.; Nam, H.; Byun, W.G.; Bae, H.; Choi, J.H.; Park, S.B.* Asian J. Org. Chem. 2019, 8, 1698–1706. (DOI: 10.1002/ajoc.201800668) (selected as a VIP paper and Cover article) (IF=2.496)
(153) Phenotype-based discovery of a HeLa cell-specific cytotoxic molecule that downregulates HPV-mediated signaling pathways via oxidative damage. Lee, S.†; Cho, W.†; Hong, S.; Kim, H.; Yi, S.; Beak, S.Y.; Jung, J.; Shin, Y.K.; Park, S.B.* Org. Biomol. Chem. 2019, 17, 7388–7397. (DOI: 10.1039/C9OB01341E) (†: equally contributed) (IF=3.490)
(152) Identification of a novel turn-on albumin binding small-molecule bioprobe in live zebrafish and its potential application in drug discovery. Chun, H.-S.; Han, S.-J.; Shin, D.-S.; Pagire, H.S.; Pagire, S.H.; Lee, G.B.; Chae, C.H.; Pak, B.; Jin, S.-W.; Chang, Y.-T.; Park, S.B.*; Ahn, J.H.*; Bae, M.A.* Dyes Pigment. 2019, 171, 107720. (DOI: 10.1016/j.dyepig.2019.107720) (IF=4.018)
(151) High mobility group box 1 secretion blockade results in the reduction of early pancreatic islet graft loss. Chung, H.; Hong, S.J.; Choi, S.W.; Koo, J.Y.; Kim, M.; Kim, H.-J.; Park, S.B.*; Park, C.-G.* Biochem. Biophys. Res. Commun. 2019, 514, 1081–1086. (DOI: 10.1016/j.bbrc.2019.05.003) (IF=2.705)
(150) Development of α-GalCer analogues with an α-fluorocarbonyl moiety as Th2-selective ligands of CD1d. Kim, H.†; Song, H.†; Park, J.-G.; Lee, D.S.; Park, S.B.* ACS Med. Chem. Lett. 2019, 10, 773–779. (DOI: 10.1021/acsmedchemlett.9b00026) (†: equally contributed) (IF: 3.737)
(149) Improved Th17 selectivity of α-galactosylceramide via noncovalent interactions with diether moiety. Hwang, Y.S.†; Yim, J.†; Song, H.†; Park, S.B.* ACS Med. Chem. Lett. 2019, 10, 720–725. (DOI: 10.1021/acsmedchemlett.8b00556) (†: equally contributed) (IF=3.794)
(148) A validated UPLC-MS/MS method for pharmacokinetic study of inflachromene, a novel microglia inhibitor. Lee. H.H.; Im, S.H.; Ahn, S.; Bae, M.A.; Park, S.B.; Kim, S.K.; Song, J.S.* J. Pharm. Biomed. Anal. 2019, 166, 183–188. (DOI: 10.1016/j.jpba.2019.01.013) (IF: 2.983)
(147) Label-free Target Identification in Drug Discovery via Phenotypic Screening. Park, H.; Ha, J.; Park, S. B.* Curr. Opin. Chem. Biol. 2019, 50, 66–72. (DOI: 10.1016/j.cbpa.2019.02.006) (IF: 8.544)
(146) Label-free target identification reveals oxidative DNA damage as the mechanism of a selective cytotoxic agent. Park, H.; Park, S. B.* Chem. Sci. 2019, 10(12), 3449–3458. (DOI: 10.1039/C8SC05465G) (Front Cover Article) (IF: 9.556)
(145) Editorial: diversity-oriented synthesis. Basso, A.*; Park, S. B.* Moni, L.* Front. Chem. 2019, 6, 668. (DOI: 10.3389/fchem.2018.00668) (Themed Issue: Diversity-Oriented Synthesis) (IF=4.155)
(144) A divergent synthetic pathway for pyrimidine-embedded medium-sized azacycles through an N-quaternizing strategy. Choi, Y.†; Kim, H.†; Park, S. B.* Chem. Sci. 2019, 10(2), 569–575. (DOI: 10.1039/C8SC04061C) (†: equally contributed) (IF=9.063)
2018
(143) Restoring let-7 microRNA biogenesis using a small-molecule inhibitor of the protein–RNA interaction. Lim, D.†; Byun, W. G.†; Park, S. B.* ACS Med. Chem. Lett 2018, 9(12), 1181-1185. (DOI: 10.1021/acsmedchemlett.8b00323) (†: equally contributed) (IF=3.794)
(142) A brief overview of two major strategies in diversity-oriented synthesis: Build/couple/pair and ring-distortion. Yi, S.†; Varun, B.V.†; Choi, Y.†; Park, S. B.* Front. Chem. 2018, 6, 507. (DOI: 10.3389/fchem.2018.00507) (†: equally contributed) (Themed Issue: Diversity-Oriented Synthesis) (IF=4.155)
(141) Near-IR fluorescent tracer for glucose-uptake monitoring in live cells. Jo, A.†; Sung, J.†; Kim, K.-R.; Lee, H. W.; Park, J.; Ahn, D.; Kim, H.; Kim, E.*; Park, S. B.* Bioconjugate Chem. 2018, 29(10), 3394-3401. (DOI: 10.1021/acs.bioconjchem.8b00558) (†: equally contributed) (IF=4.485)
(140) Monochromophoric design strategy for tetrazine-based colorful bioorthogonal probes with a single fluorescent core skeleton. Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc. 2018, 140(3), 974-983. (DOI: 10.1021/jacs.7b10433) (Selected as Cover Article) (IF=13.858)
2017
(139) Structural basis for the enhanced anti-diabetic efficacy of lobeglitazone on PPARγ. Jang, J. Y.; Bae, H.; Lee, Y. J.; Choi, Y. I.; Kim, H.-J.; Park, S. B.; Suh, S. W.; Kim, S. W.*; Han, B. W.* Sci. Rep. 2017, 8, 31. (DOI: 10.1038/s41598-017-18274-1) (IF=4.259)
(138) Comparative study for electrical transport characteristics of self-assembled monolayers formed by benzenethiol, cyclohexanethiol, and adamantanethiol. Kim, J.; Jeong, H.; Seong, S.; Kim, M.; Kim, D.; Hwnag, W.-T.; Jang, Y.; Choi, B.Y.; Koo, J.; Park, S. B.; Noh, J.; Lee, T.* Curr. Appl. Phys. 2017, 17(11), 1459-1464. (DOI: 10.1016/j.cap.2017.08.013) (IF=2.144)
(137) Development of fluorescent mitochondria probe based on 1,2-dihydropyrrolo[3,4-b]indolizine-3-one. Sung, J.; Lee, Y.; Cha, J.-H.; Park, S. B.*; Kim, E.* Dyes Pigment. 2017, 145, 461-468. (DOI: 10.1016/j.dyepig.2017.06.014) (IF 4.055)
(136) Structural basis for differential activities of enantiomeric PPARγ agonists: Binding of S35 to the alternate site. Jang, J.Y.; Koh, M.; Bae, H.; An, D.R.; Im, H.N.; Kim, H.S.; Youn, J.Y.; Yoon, H.-J.; Han, B.W.; Park, S.B.; Suh, S.W.* BBA - Proteins ans Proteomics 2017, 1865(6), 674-681. (DOI: 10.1016/j.bbapap.2017.03.008) (IF 3.016)
(135) Synthesis of 3,5-disubstituted isoxazoles containing privileged substructures with a diverse display of polar surface area. Kim, M.; Hwang, Y.S.; Cho, W.; Park, S.B.* ACS Comb. Sci. 2017, 19(6), 407-413. (DOI: 10.1021/acscombsci.7b00032) (IF: 3.317)
(134) Gold-catalyzed unexpected ring transformation of pyrimidodiazepine derivatives. Koo, J.; Kim, J.; Park, S. B.* Org. Lett. 2017, 19(2), 344-347. (DOI: 10.1021/acs.orglett.6b03520) (IF=6.732)
(133) Treatment of sepsis pathogenesis with high mobility group box protein 1-regulating anti-inflammatory agents. Cho, W.†; Koo, J.Y.†; Park, Y.; Oh, K.; Lee, S.; Song, J.-S.; Bae, M.A.; Lim. D.; Lee, D.-S.; Park, S.B.* J. Med. Chem. 2017, 60(1), 170-179. (DOI: 10.1021/acs.jmedchem.6b00954) (IF=5.589)
(132) Label-free target identification using in-gel fluorescence difference via thermal stability shift. Park, H.; Ha, J.; Koo, J.Y.; Park, J.; Park, S.B.* Chem. Sci. 2017, 8(2), 1127-1133. (DOI: 10.1039/C6SC03238A) (IF=9.144)
2016
(131) BOIMPY: Fluorescent boron complexes with tunable and environment-responsive light-emitting properties. Lee, B.; Park, B.G.; Cho, W.; Lee, H.Y.; Olaz, A., Chen, C.-H.; Park, S.B.*; Lee, D.* Chem. Eur. J. 2016, 22(48), 17321-17328. (DOI: 10.1002/chem.201603837) (IF=5.771)
(130) Regenerative fluorescence “turn-on” probe for biothiols through Cu(II)/Cu(I) redox conversion. Lee, K.-S.; Park, J.; Park, H.-J.; Chung, Y.K.; Park, S.B. ; Kim, H.-J.*; Shin, I.-S.*; Hong, J.-I* Sensor Actuat. B- Chem. 2016, 237, 256-261. (DOI: 10.1016/j.snb.2016.06.089) (IF=4.80)
(129) Discovery of small-molecule inhibitor of protein–microRNA interaction using binding assay with a site-specifically labeled Lin28. Lim, D.; Byun, W.G.; Koo, J.Y.; Park, H.; Park, S.B.* J. Am. Chem. Soc. 2016, 138, 13630-13638. (DOI: 10.1021/jacs.6b06965) (IF=13.038)
(128) Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction. Kim, J.†; Jung, J.†; Koo, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nat. Commun. 2016, 7, 13196. (DOI: 10.1038/ncomms13196) (IF=11.329)
(127) Readily accessible and predictable naphthalene-based two-photon fluorophore with full visible-color coverage. Koo, J.Y.; Heo, C.H.; Shin, Y.; Kim, D.; Lim, C.S.; Cho, B.R.; Kim, H.M.; Park, S.B.* Chem. Eur. J. 2016, 22, 14166-14170. (DOI: 10.1002/chem.201603496) (IF=5.771)
(126) A novel small-molecule agonist of PPAR-γ potentiates an anti-inflammatory M2 glial phenotype. Song, K.J.; Nam, Y.; Jung, M.; Jo, M.; Koo, J.Y.; Cho, W.; Koh, M; Park, S. B.*; Suk, K.* Neuropharmacology 2016, 109, 159-169. (DOI: 10.1016/j.neuropharm.2016.06.009) (IF=4.936)
(125) Mechanistic elucidation guided by covalent inhibitors for the development of anti-diabetic PPARγ ligands. Bae, H.; Jang, J.Y.; Choi, S.-S.; Kim, H, Jo, A.; Choi, J.H.; Suh, S.W.; Park, S.B.* Chem. Sci. 2016, 7, 5523-5529. (DOI: 10.1039/C6SC01279E) (IF=9.144)
(124) A pyrazolo[1,5-a]pyridine-fused pyrimidine based novel fluorophore and its bioapplication to probing lipid droplets. Kim, H.; Jo, A.; Ha, J.; Lee, Y.; Hwang, Y.S.; Park, S.B.* Chem. Comm. 2016, 52, 7822-7825. (DOI: 10.1039/C6CC02184K) (IF=6.567)
(123) A high-content screening platform with fluorescent chemical probes for the discovery of first-in-class therapeutics. Jo, A.†; Jung, J.†; Kim, E.; Park, S.B.* Chem. Comm. 2016, 52, 7433-7445. (DOI: 10.1039/C6CC02587K) (Invited Feature Article) (IF=6.567)
(122) Nonspecific protein labeling of photoaffinity linkers correlates with their molecular shapes in living cells. Park, H.†; Koo, J.Y.†; Srikanth, Y.V.V.; Lee, J.; Park, J.*; Park, S. B.* Chem. Commun. 2016, 52, 5828-5831. (DOI: 10.1039/C6CC01426G) (IF=6.567)
(121) β-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase. Kim, C.†; Jung, J.†; Tung, T.T.; Park, S.B.* Chem. Sci. 2016, 7, 2753-2761. (DOI: 10.1039/c5sc03493k) (IF=9.144)
(120) PPARγ antagonist gleevec improves insulin sensitivity and promotes the browning of white adipose tissue. Choi, S.; Kim, E.-S.; Jung, J.-E.; Marciano, D.; Jo, A.; Koo, J.Y.; Choi, Y.C.; Yang, Y.R.; Jang, H.-J.; Kim, E.-K.; Kwon, H.M.; Lee, I.H.; Park, S.B.; Suh, P.-G.; Griffin, P.R.; Choi, J.H.* Diabetes 2016, 65(4), 829-839. (DOI: 10.2337/db15-1382) (IF=8.474)
(119) Investigation of specific binding proteins to photoaffinity linkers for efficient deconvolution of target protein. Park, J.*; Koh, M.; Koo, J. Y.; Lee, S.; Park, S.B.* ACS Chem. Biol. 2016, 11(1), 44-52. (DOI: 10.1021/acschembio.5b00671) (IF=5.356)
2015
(118) Rational Improvement of Molar Absorptivity Guided by Oscillator Strength: A Case Study with Furoindolizine-based Core Skeleton. Lee, Y.; Jo, A.;Park, S.B.* Angew. Chem. Int. Ed. 2015, 54(52),15689-15693. (IF: 11.336)
(117) Diverse Display of Non-covalent Interacting Elements using Pyrimidine-Embedded Polyheterocycles. Choi, Y.†; Kim, H.†; Shin, Y.-H.; Park, S.B.* Chem. Comm. 2015, 51, 13040–13043. (IF: 6.834)
(116) Orphan nuclear receptor Estrogen-related receptor γ (ERRγ) plays a key role in Hepatic Cannabinoid Receptor Type 1-mediated Induction of CYP7A1 Gene Expression. Zhang, Y.; Kim, D.-K.; Lee, J.-M.; Park, S.B.; Jeong, W.-I.; Kim, S.H.; Lee, I.-K.; Lee, C.-H.; Chiang, J.Y.L.; Choi, H.-S.* Biochem. J., 2015, 470, 181–193. (IF: 4.396)
(115) Unique Photophysical Properties of 9-Styryl-1,2-dihydropyrrolo[3,4- β]indolizin-3-one and Their Efficient Synthesis via Direct C-H Activation. Choi, E.; Park, S.B.* Org. Biomol. Chem. 2015, 13, 5202-5208. (IF: 3.487)
(114) Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Kim, J.I.; Huh, J.Y.; Sohn, J.H.; Choe, S.S.; Lee, Y.S.; Lim, C.Y.; Jo, A.; Park, S.B.; Han, W.; Kim, J.B. Mol. Cell. Biol. 2015, doi:10.1128/MCB.01321-14
(113) Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor. Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547. (IF: 24.348)
2014
(112) A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nat. Chem. Biol. 2014, 10(12), 1055–1060. (IF: 13.217)
(111) Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces. Kim, J.; Kim, H.; Park, S.B.* J. Am. Chem. Soc. 2014, 136(42), 14629–14638. (invited Perspective) (IF: 11.444)
(110) A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity. Choi, S.-S.; Kim, E.S.; Koh, M.; Lee, S.-J.; Lim, D.; Yang, Y.R.; Jang, H.-J.; Park, S.B.; Suh, P.-G.; Choi, J.H.* J. Biol. Chem. 2014, 289(38), 26618–26629.
(109) Discovery of carbohybrid-based 2-aminopyrimidine analogues as multi-stage active antimalarial agents using image-based cytological profiling assay. Lee, S.; Lim, D.; Lee, E.; Lee, N.; Lee, H.-G.; Cechetto, J.; Liuzzi, M.; Freitas-Junior, L.H.; Song, J.S.; Bae, M.A.; Oh, S.; Ayong, L.*; Park, S.B.* J. Med. Chem. 2014, 57(17), 7425–7434.
(108) Impact of molecular charge on GLUT-specific cellular uptake of glucose bioprobes and in vivo application of the glucose bioprobe, GB2-Cy3. Park, J.; Um, J.I.; Jo, A.; Lee, J.; Jung, D.-W.; Williams, D.*; Park, S. B.* Chem. Commun. 2014, 50(66), 9251–9254. (Selected as Front Cover) (IF: 6.378)
(107) Phenotypic Screening to Identify Small-Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy. Koh, M.; Park, J.; Koo, J.Y.; Lim, D.; Cha, M.Y.; Jo, A.; Choi, J.H.; Park, S. B.* Angew. Chem. Int. Ed. 2014, 53(20), 5102–5106. (selected as Cover Article) (IF: 13.734)
(106) Inverse agonist of ERRgamma controls Salmonella typhimurium infection by modulating host iron homeostasis. Kim1, D.-K.; Jeong, J.-H.; Lee, J.-M.; Kim, K.S.; Park, S.-H.; Kim, Y.D.; Koh, M.; Shin, M.; Jung, Y.S.; Kim, H.-S.; Lee, T.-H.; Oh, B.-C.; Kim, J. I.; Park, H.T.; Jeong, W.-I.; Lee, C.-H.; Park, S.B.; Min, J.-J.; Jung, S.-I.; Choi, S.-Y.; Choy, H.E.*; Choi, H.-S.* Nat. Med. 2014, 20, 419–424. (IF: 22.864)
(105) Anti-inflammatory effects of a-galactosylceramide analogs in activated microglia; involvement of p38 MAPK signaling pathway. Jeong, Y.-H.; Kim, Y.; Song, H.; Park, S.B.*; Kim, H.-S.* PLoS ONE 2014, 9(2), e87030. (IF: 3.730)
(104) Rational Perturbation of the Fluorescence Quantum Yield in Emission-Tunable and Predictable Fluorophores (Seoul-Fluors) by a Facile Synthetic Method Involving C-H Activation. Choi, E.; Kim, E.; Lee, Y.; Jo, A.; Park, S. B.* Angew. Chem. Int. Ed. 2014, 53(5), 1346-1350. (IF: 13.734)
(103) Synthesis and Library Construction of privileged tetra-substituted ∆5-2-oxopiperazine as β-turn structure mimetic. s. Kim, J.; Lee, W. S.; Koo, J.; Lee, J.; Park, S. B.* ACS Comb. Sci. 2014, 16(1), 24–32. (IF: 3.636)
2013
(102) Estrogen-related receptor gamma induces cardiac hypertrophy by activating GATA4. Kwon, D.H.; Eom, G.H.; Kim, D.K.; Koo, J.Y.; Lim, H.S.; Nam, G.-I.; Kim, K.K.; Lee, I.-K.; Park, S.B.; Choi, H.-S.; Kook, H.* Journal of Molecular and Cellular Cardiology 2013 65, 88-97. (IF: 5.150)
(101) Privileged Substructure-Based Diversity-Oriented Synthesis Pathway for Diverse Pyrimidine-Embedded Polyheterocycles. Kim, H.; Tung, T. T.; Park, S. B.* Org. Lett. 2013 15(22), 5814–5817. (IF: 6.142)
(100) Measurement of Lipid Droplet Accumulation Kinetics in Chlamydomonas reinhardtii Using Seoul-Fluor. Park, J.W.; Na, S. C.; Lee, Y.; Lee, S.; Park, S. B.*; Jeon, N.R.* Energies 2013 6(11), 5703–5716. (IF: 1.844)
(99) Synthesis and Biological Evaluation of α-Galactosylceramide Analogues with Heteroaromatic Rings and Varying Positions of Phenyl Group in the Sphingosine Backbone. Kim, Y.; Oh, K.; Song, H.; Lee, D.-S.; Park, S. B.* J. Med. Chem. 2013 56(17), 7100–7109. (IF: 5.614)
(98) The O-glycosylation mutant osteopontin alters lung cancer cell growth and migration in vitro and in vivo. Minai-Tehrani, A.; Chang, S.H.; Park, S.B.; Cho, M.-H.* International Journal of Molecular Medicine 2013, 32(5), 1137–1149. (IF: 1.957)
(97) Bio-inspired melanin like nanoparticles as a highly efficient contrast agent for T1-weighted magnetic resonance imaging. Ju, K.-Y.; Lee, J.W.; Im, G.H.; Lee, S.; Pyo, J.; Park, S.B.; Lee, J.H.; Lee, J.-K.* Biomacromolecules 2013, 14(10), 3491–3497. (IF: 5.48)
(96) Inverse agonist of nuclear receptor ERRg mediates anti-diabetic effect through inhibition of hepatic gluconeogenesis. Kim, D.-K.; Gang, G.-T.; Ryu, D.; Koh, M.; Kim, Y.-N.; Kim, S.S.; Park, J.; Kim, Y.-H.; Sim, T.; Lee, I.-K.; Choi, C.S.; Park, S.B.*; Lee, C.-H.*; Koo, S.-H.*; Choi, H.-S.* Diabetes 2013 62(9), 3093–3102. (IF: 7.895)
(95) Discovery of autophagy modulators through the construction of high-content screening platform via monitoring of lipid droplets. Lee, S; Kim, E.; Park, S.B.* Chem. Sci. 2013 4, 3282–3287. (IF: 8.314)
(94) Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol. Kim, D.-K.; Kim, Y.-H.; Jang, H.-H.; Park, J.; Kim, J. R.; Koh, M.; Jeong, W.-I.; Koo, S.-H.; Park, T.-S.; Yun, C.-H.; Park, S.B.; Chiang, J.Y.L.; Lee, C.-H.; Choi, H.-S.* GUT 2013, 72(7), 1044–1054. (IF: 10.732)
(93) Exploiting the mechanism of cellular glucose uptake to develop an image-based high-throughput screening system in living cells. Jo, A; Park, J.; Park, S.B.* Chem. Comm., 2013 49(45), 5138–5140 (Back Cover Article) (IF: 6.378)
(92) Total Synthesis of Eryvarin H and its Derivatives and their Biological Activity as ERRγ Inverse Agonist. Koo, J.Y.; Oh, S.; Cho, S.-L.; Koh, M.; Oh, W.-K.; Choi, H.-S.*; Park, S. B.* Org. Biomol. Chem. 2013 11(35), 5782–5786. (IF: 3.568)
(91) Focus on chemical biology in Asia. Yoshida, M.; Park, S.B.; Boone, C. Molecular BioSystems 2013 9, 825. (IF: 3.534) Editorial of “Chemical Biology in Asia”. (IF: 3.350)
(90) From Noncovalent to Covalent Bonds: A Paradigm Shift in Target Protein Identification. Park, J.; Koh, M.; Park, S.B.* Molecular BioSystems 2013 9(4), 544–550. (IF: 3.534) Invited for the special issue for “Editorial Board Issue” (Front Cover Article) (IF: 3.350)
(89) Synthesis of Molecular Frameworks Containing Two Distinct Heterocycles Connected in a Single Molecule with Enhanced 3-Dimensional Shape Diversity. . Lim, D.; Park, S.B.* Chem. Eur. J. 2013 19(22), 7100–7108. (IF: 5.831)
(88) Optimization of Seoul-Fluor-Based Lipid Droplet Bioprobes and their Application in Microalgae for Bio-Fuel Study. . Lee, Y.; Na, S.; Lee, S.; Jeon, N.L.*; Park, S.B.* Molecular BioSystems 2013 9(5), 952–956. (IF: 3.534) Invited for the special issue for “Chemical Biology in Asia”. (IF: 3.350)
(87) Discovery of highly selective FLT3 kinase inhibitor from phenotypic cell viability profiling. Lee, S.; Jo, A.; Park, S.B.* Med. Chem. Comm. 2013 4(1), 228–232. (Front Cover Article) Invited for the themed issue highlighting “New Talent” in Medicinal Chemistry (IF: 2.722)
(86) Fluorescent Chemosensor for Biological Zinc Ions. Bae, S. W.; Kim, E.; Shin, I.-S.; Park, S.B.*; Hong, J.-I.* Supramolecular Chem. 2013 25(1), 2–6. (IF: 1.546)
2012
(85) Establishment of High Throughput Screening System Using Human Umbilical Cord-derived Mesenchymal Stem Cells. Park, E. G.; Cho, T.; Oh, G.; Kwon, S.-K.; Lee, D.-S.; Park, S.B.; Cho, J.* Int. J. Oral Biol. 2012, 37(2), 43–50.
(84) Colorimetric and orange light-emitting fluorescent probe for pyrophosphate in water. Lee, D.-N.; Jo, A.; Park, S.B.*; Hong, J.-I.* Tetrahedron Lett. 2012 53(41), 5528–5530. (IF: 2.397)
(83) Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRg. Lee, J. H.; Kim, E.-J.; Kim, D.-K.; Lee, J.-M.; Park, S. B.; Lee, I.-K.; Harris, R. A.; Lee, M.-O. *; Choi, H.-S.* PLoS One 2012 7(9), e46324. (IF: 4.092)
(82) A potent small-molecule inducer of chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells Cho, T.-J.‡; Kim, J.‡;Kwon, S.-K.; Oh, K; Lee, J.-A.; Lee, D.-S.; Cho, J.*; Park, S. B.* Chemical Science 2012, 3(10), 3071–3075. (IF: 7.525)
(81) Lentiviral Vector-mediated shRNA against AIMP2-DX2 Suppresses Lung Cancer Cell Growth through Blocking Glucose UptakeChang, S.-H.; Chung, Y.-S.; Hwang, S.-K.; Kwon, J.-T.; Minai-Tehrani, A.; Kim, S.; Park, S. B.; Kim, Y.-S.; Cho, M.-H.* Mol. Cells 2012, 33(6):553–562.(IF: 2.178)
(80) Selective Seoul-Fluor-based Bioprobe, SfBP, for Vaccinia H1-related Phosphatase—a Dual-Specific Protein Tyrosine PhosphataseJeong, M.S.; Kim, E..; Kang, H.J.; Choi, E.J.; Chung, S.J.*; Park, S. B.* Chem. Commun. 2012, 48(52), 6553–6555(IF: 6.169).
(79) Discovery and Target Identification of an Antiproliferative Agent in Live Cells using Fluorescence Difference in Two Dimensional Gel ElectrophoresisPark, J.; Oh, S.; Park, S. B.* Angew. Chem. Int. Ed. 2012, 51, 5447–5451(IF: 13.455) (Front cover article).
(78) Orphan Nuclear Receptor ERRg is a Key Regulator of Hepatic Gluconeogenesis Kim, D.-K.; Ryu, D.; Koh, M.; Lee, M.-W.; Kim, M.-J.; Cho, W.-J.; Lee, C.-H.;Park, S.B.*; Koo, S.-H.*; Choi, H.-S.* J. Biol. Chem. 2012 287(26), 21628–21639.(IF: 4.773)
(77) Family-Selective Detection of Antibiotics using Antibody-Functionalized Carbon Nanotube Sensors Kim, B.; Lim, D.; Jin, H. J.; Lee, H. Y.; Seon, N.; Ko, Y.; Park, S. B.*; Hong, S.* Sensors & Actuators: B. Chemical 2012, 166-167, 193–199. (IF: 3.898)
(76) Synthesis and Biological Evaluation of Pyrimidine-based Dual Inhibitors of Human Epidermal Growth Factor Receptor-1 (HER-1) and HER-2 Tyrosine KinasesCha, M.Y.; Lee, K.-O.; Kang, S.-J.; Jung, Y.H.; Song, J.Y.; Choi, K.J.; Byun, J.Y.; Lee, H.-J.; Lee, G.S.; Park, S. B.*; Kim, M.S.* J. Med. Chem. 2012, 55(6), 2846–2857. (IF: 5.207)
(75) Photochemical generation of a new, highly fluorescent compound from resveratrol Yang, I.; Kim, E.; Kang, J.; Han, H.; Sul, S.; Park, S. B.*; Kim, S. K.* Chem. Commun. 2012, 48(32), 3839–3841 (IF: 6.169).
(74) De Novo Analysis of Protein N-terminal Sequence Utilizing MALDI Signal Enhancing Derivatization with Br Signiture Kim, J.-S.; Song, J.-S.; Kim, Y.; Park, S. B.; Kim, H.-J.* Anal Bioanal. Chem. 2012 402(5), 1911–1919. (IF: 3.778)
(73) Antitumor Activity of HM781-36B, an Irreversible EGFR/HER-2 Inhibitor Highly Effective in EGFR-dependent Cancer Models Including Erlotinib-Resistant NSCLC. Cha, M.Y.; Lee, K.-O.; Kim, M.; Chae, Y.J.; Song, J.Y.; Lee, G.H.; Kim, Y.H.; Suh, K.H.; Park, S.B.*; Kim, M.S.* Int. J. Cancer 2012, 130(10), 2445–2454. (IF: 5.444)
(72) Heteroaromatic Moieties in the Sphingosine Backbone ofa-Galactosylceramides for Noncovalent Interactions with CD1d.Kim, Y.; Kim, J.; Oh, K.; Lee, D.-S.; Park, S. B.* ACS Med. Chem. Lett. 2012, 3(2), 151–154. (IF: 3.355)
(71) Seoul-Fluor-based Bioprobe for Lipid Droplet and its Application in Image-based High-Throughput Screening Kim, E.; Lee, S.; Park, S. B.* Chem. Commun. 2012, 48(17), 2331–2333. (IF: 6.169)
(70) Construction of Polyheterocyclic Benzopyran Library with Diverse Core Skeletons through Diversity-Oriented Synthesis Pathway: Part IIZhu, M.; Lim, B. J.; Koh, M.; Park, S. B.* ACS Comb. Sci. 2012, 14(2), 124–134. (IF: 3.408)
(69) Regioselective Construction and Screening of 1,3-Disubstituted Tetrahydroindazolones in Enantio-merically Pure Pairs Song, H.; Lee, H.; Kim, J.; Park, S. B.* ACS Comb. Sci. 2012, 14(1), 66–74. (IF: 3.408)
2011
(68) Highly selective fluorescence turn-on probe for glutathione Lim, S.-Y.; Lee, S.; Park, S. B.*; Kim, H.-J.* Tetrahedron Lett. 2011, 52, 3902–3904(IF: 2.660)
(67) Diversity-Oriented Synthesis of Functionalized Polyheterocycles from Garner Aldehyde. Srivastava, A.K.; Song, H.; Park, S.B.* Synthesis (invited)2011, 14, 2215–2222(IF: 2.572)
(66) Estrogen-related Receptor gamma (ERRg) is a Novel Transcriptional Regulator of Phosphatidic Acid Phosphatase, LIPIN1, and Inhibits Hepatic Insulin Signaling. Kim, D.-K.; Kim, J. R.; Koh, M.; Kim, Y. D.; Lee, J.-M.; Park, S. B.; Min J.J.; Park, T.-S.; Choi, H.-S.* J. Biol. Chem. 2011 286(44), 38035–38042 (IF:5.33).
(65) 9-Aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one (Seoul-Fluor) as a smart platform for colorful ratiometric fluorescent pH sensors Kim, E.; Lee, S.; Park, S. B.* Chem. Commun. 2011 47(27), 7734–7736. (IF: 6.169)
(64) Development of a FRET-based High Throughput Screening System for the Discovery of Hsp90 Inhibitors. Oh, S.; Ko, Y.; Lee, H.; Park, S.B.* B. Kor. Chem. Soc. 2011, 32,3229–3232(Cover image)
(63) Ratiometric Analysis of Zidovudine(ZDV) Incorporation by Reverse Transcriptases or Polymerases via Bio-orthogonal Click Chemistry. Koh, M.; Park, J.; An, H.; Park, S. B.* Chem. Commun. 2011 47(27), 7614–7616. (IF: 6.169)
(62) A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators. Oh, S.; Park, S.B.* Chem. Commun. 2011, 12754–12761 (Featured Article)(IF: 6.169)
(61) Bioinspired Polymerization of Dopamine to Generate Melanin Nanoparticles Having Excellent Free Radical-Scavenging Property Ju, K.-Y.; Lee, Y.; Lee, S.; Park, S.B.; Lee, J.-K.* Biomacromolecules 2011, 12(3), 625–632. (IF: 4.502)
(60) Solid-Phase Parallel Synthesis of Tetrahydroindazolone Library Containing Three Unique Core Skeletons. Kim, J.; Song, H.; Park, S.B.* Chem. –Asian J. 2011 6, 2062–2072. (IF: 4.500)
(59) Emission Wavelength Prediction of a Full-Color-Tunable Fluorescent Core Skeleton, 1,2-Dihydropyrrolo[3,4-β]indolizin-3-one. Kim, E.; Koh, M.; Lim, B.J.; Park, S.B.* J. Am. Chem. Soc. 2011 133, 6642–6649.(IF: 9.907)
(58) A Synthetic Route to Highly Substituted 1,2,3,4-Tetrahydroisoquinolines via Yb(OTf)3-catalyzed Diastereoselective Ring Opening of Bridgehead Oxazolidines. Srivastava, A.K.; Koh, M.; Park, S.B.* Chem. Eur. J. 2011 17(17), 4905–4913(IF: 5.476)
(57) Pharmacophore-based Strategy for the Development of General and Specific scFv Biosensors for Abused Antibiotics. Cha, M.Y.; Lee, H.Y.; Ko, Y.; Shim, H.; Park, S.B.* Bioconjugate Chem. 2011 22(1), 88–94. (IF: 4.930)
(56) A Newly Identified CG301269 Improves Lipid and Glucose Metabolism without Body Weight Gain through Activation of PPARa and PPARg. Jeong, H.W.; Lee, J.-W.; Kim, W.S.; Choe, S.S.; Kim, K.-H.; Park, H.S.; Shin, H.J.; Lee, G.Y.; Shin, D.; Lee, H.; Lee, J.H.; Choi, E.B.; Lee, H.K.; Chung, H.; Park, S.B.; Park, K.S.; Kim, H.-S.; Ro, S.; Kim, J.B.* Diabetes. 2011 60, 496–506. (IF: 8.505)
(55) Development of Fluorescent Glucose Bioprobes and their Application on Real-time and Quantitative Monitoring of Glucose Uptake in Live Cells. Lee, H.Y.; Lee, J.J.; Park, J.; Park, S.B.* Chem. Eur. J. 2011, 17(1), 143–150. (IF: 5.925) [This article is selected as inside cover image and featured as “spotlights” by Angew. Chem. Int. Ed. 2011, 50(1), 30–32].
(54) Surface modification for small molecule microarray and its application for the discovery of tyrosinase inhibitors. Lee, H. Y.; Park, S.B.* Mol. BioSys. 2011, 7(2), 304–310. (IF: 4.015) This article is part of the 2011 Molecular BioSystems ‘Emerging Investigators’ issue: highlighting the work of outstanding young scientists at the chemical- and systems-biology interfaces.
(53) Discovery of a Novel Benzopyranyl Compound as a Potent In Vitro and In Vivo Osteogenic Agent. Oh, S.; Yang, J.-Y.; Sun, H.J.; Jung, J.Y.; Cho, S.W.; Shin, C.S.*; Park, S.B.* Med. Chem. Commun. 2011, 2(1), 76–80. (IF: 2.800)
(52) Computer-aided design and synthesis of tetra-aryl-substituted alkenes and their bioevaluation as a selective modulator of estrogen related receptor γ Koh, M.; Park, S.B.* Molecular Diversity 2011, 15, 69–81. (IF: 3.821)
2010
(51) Discovery of Novel Benzopyranyl Tetracyclecs that Act as Inhibitors of RANKL-induced Osteoclastogenesis. Zhu, M.; Kim, M.H.; Lee, S.; Kim, S.H.; Park, S.B.* J. Med. Chem. 2010, 53(24), 8760–8764.(IF: 5.207)
(50) Anti-diabetic and anti-obesity effects of ampkinone, a novel small molecule activator of AMP-activated protein kinase (AMPK). Kim, S.J.; Oh, S.; Hwang, J.H.; Lee, H.Y.; Ryu, M.J.; Kim, S.J.; Jo, Y.S.; Park, J.; Kim, Y.K.; Lee, C.-H.; Kweon, K.R.; Shong, M.*;Park, S.B.* J. Med. Chem. 2010 53, 7405–7413. (IF: 5.207)
(49) Construction of Polyheterocyclic Benzopyran Library with Diverse Core Skeletons through Diversity-Oriented Synthesis Pathway. Oh, S.; Jang, H.J.; Ko, S.K.; Ko, Y.; Park, S.B.* J. Comb. Chem. 2010, 12, 548–558 (IF: 3.450)
(48) A Nonthiazolidinedione Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist CG301360 Alleviates Insulin Resistance and Lipid Dysregulation in db/db Mice. Jeong, H.W.; Lee, J.-W.; Kim, W.S.; Choe, S.S.; Shin, H.J.; Lee, G.Y.; Shin, D.; Lee, J.H.; Choi, E.B.; Lee, H.K.; Yon, G.H.; Cho, B.; Kim, H.R.; Choi, S.H.; Chung Y.S.; Park, S.B.; Chung, H.; Ro, S.; Kim, J.B.* Molecular Pharmacology. 2010, 78, 877–885. (IF: 4.531)
(47) Orthogonal Regioselective Synthesis of N-alkyl-3-substituted Tetrahydroindazolones Kim, J.; Song, H.; Park, S.B.* Eur. J. Org. Chem. 2010, 3815–3822 (selected as a cover image, selected as a highlight by Synfact) (IF: 3.096)
(46) Crystal structure of Tpa1 from Saccharomyces cerevisiae, a component of the messenger ribonucleo-protein complex Kim, H.S.; Kim, H.L.; Kim, K.H.; Kim, D.J.; Lee, S.J.; Yoon, J.Y.; Yoon, H.J.; Lee, H.Y.; Park, S.B.; Kim, S.-J.; Lee, J.Y.; Suh, S.W.* Nucleic Acids Research 2010, 38(6), 2099–2110. (IF: 7.479)
(45) Development of a Benzopyran-containing Androgen Receptor Antagonist to Treat Antiandrogen-resistant Prostate Cancer Oh, S.; Park, J.; Nam, H.J.; Beak, S.H.*;Park, S.B.* ChemMedChem. 2010 5(4), 529–533 (IF: 3.232).
2009
(44) An Efficient One-step Synthesis of Hetero-biaryl Pyrazolo[3,4-b]pyridines via Indole-ring Opening Lee, S.; Park, S.B.* Org. Lett. 2009, 11(22), 5214–5217(IF: 5.862)
(43) Discovery of A Novel Her-1/Her-2 Dual Tyrosine Inhibitor for the Treatment of Her-1 Selective Inhibitor-resistant Non-small Cell Lung Cancer Cha, M.Y.; Lee, K.-O.; Kim, J.W.; Lee, C.G.; Song, J.Y.; Kim, Y.H.; Lee, G.S.; Park, S.B.*; Kim, M.S.* J. Med. Chem. 2009, 52, 6880–6888(IF: 5.207)
(42) Anti-Obesity Agents: a Focused Review on the Structural Classification of Therapeutic Entities Oh, S.; Kim, K.S.; Shong, M.*; Park, S.B.* Current Topics in Medicinal Chemistry, 2009, 9(6), 466–481. (IF: 4.248)
(41) Chemistry as a Prism: A Review of Light-Emitting Materials Having Tunable Emission Wavelengths Kim, E.; Park, S.B.* Chemistry–An Asian Journal (invited review) 2009, 4(11), 1646–1658. (IF: 4.188)
(40) A Two-Photon Tracer for Glucose Uptake Tian, Y. S.; Lee. H.Y.; Lim, C.S.; Park, J.; Kim, H.M.; Shin, Y.N.; Kim, E.S.; Jeon, H.J.; Park, S.B.*; Cho, B.R.* Angew. Chem. Int. Ed. 2009, 48, 8027–8031(IF: 12.735)
(39) Repeated Aerosol Delivery of Carboxy-terminal Modulator Protein Suppresses Tumor in the Lungs of K-rasLA1 Mice. Hwang, S.-K.; Lim, H.-T.; Arash, M.-T.; Lee, E.-S.; Park, J.; Park, S.B.; Beck Jr, J. R.; Cho, M.-H.* Am. J. Resp. Crit. Care. Med. 2009 179(12), 1131–1140. (IF: 9.792)
(38) Transcriptional Corepressor SMILE Recruits SIRT1 to Inhibit Nuclear Receptor ERRg Transactivation Xie, Y.-B.; Park, J.-H.; Kim, D.-K.; Hwang, J.H.; Oh. S.; Park, S.B.; Shong, M.; Lee, I.-K.; Choi, H.-S.* J. Biol. Chem. 2009, 284(42), 28762–28774. (IF: 5.520)
(37) Natural Polyphenols Antagonize the Antimyeloma Activity of Proteasome Inhibitor Bortezomib by Direct Chemical Interaction Kim, T.Y.; Park, J.; Oh, B.; Min, H.J.; Jeong, T.-S.; Lee, J.H.; Suh, C.; Cheong, J.-W.; Kim, H.J.; Yoon, S.S.; Park, S.B.*; Lee, D.S.* British Journal of Hematology, 2009 146(3), 270–281 (IF: 4.490)
(36) Efficient Discovery of Selective Small Molecule Agonists of Estrogen-related Receptorg (ERRg) using Combinatorial Approach. Kim, Y.; Koh, M.; Kim, D.-K.; Choi, H.-S.; Park, S. B.* J. Comb. Chem., 2009, 11, 928–937. (IF: 3.154)
(35) Fluorescent Probe for Detection of Fluoride in Water and Bioimaging in A549 Human Lung Carcinoma Cells Kim, S.Y.; Park, J.; Koh, M.; Park, S.B.*; Hong, J.-I.* Chem. Commun. 2009 4735–4737(IF: 5.787)
(34) Efficient Parallel Synthesis of Privileged Benzopyranylpyrazoles via Regioselective Condensation of β-keto Aldehydes with Hydrazines. Park, S.; Kim, J.; Koh, M.; Park, S. B.* J. Comb. Chem. 2009, 11, 315–326. (IF: 3.154)
(33) Diastereoselective Synthesis of Polycyclic Acetal-fused Pyrano[3,2-c]pyran-5(2H)-one derivatives Sagar, R.; Park, J.; Koh, M.; Park, S.B.* J. Org. Chem. 2009, 74, 2171–2174. (IF: 3.959)
(32) Regioselective Synthesis of Tetrasubstituted Pyrroles by 1,3-Dipolar Cycloaddition and Spontaneous Decarboxylation Kim, Y.J.; Kim, J.; Park, S.B.* Org. Lett. 2009, 11, 17–20. (IF: 5.250)
2008
(31) Biomimetic Asymmetric Total Synthesis of (-)-Laurefucin via an Organoselenium-mediated Intramolecular Hydroxyetherification Kim, B.; Lee, M.; Kim, M. J.; Lee, H.; Kim, S.; Kim, D.*; Koh, M.; Park, S.B.; Shin, K. J. J. Am. Chem. Soc 2008, 130, 16807–16811. (IF: 9.019)
(30) An Improved Synthesis of Pyrimidine- and Pyrazole-based Acyclo-C-nucleosides as Carbohybrids Sagar, R.; Kim, M.-J.; Park, S.B.* Tetrahedron Letters 2008 49, 5080–5083. (IF: 2.615)
(29) Combinatorial Discovery of Full-Color-Tunable Emissive Fluorescent Probes using a Novel Core Skeleton: 1,2-dihydropyrrolo[3,4-β]indolizin-3-one Kim, E.; Ryu, J.; Koh, M.; Park, S.B.* J. Am. Chem. Soc. 2008, 130, 12206–12207. (IF: 9.019)
(28) Facile and Efficient Synthesis of Carbohybrids as Stereodivergent Druglike Small Molecules Sagar, R.; Park, S.B.* J. Org. Chem. 2008, 73, 3270–3273. (IF: 3.790)
(27) Diversity-oriented Synthesis of Privileged Benzopyranyl Heterocycles from S-cis Enones. An, H.; Eum, S.J.; Ko, M.; Lee, S. K.; Park, S. B.* J. Org. Chem 2008, 73, 1752–1761. (IF: 3.790)
Before 2008
2007
(26) Development of novel Cy3-labeled glucose bioprobe and its application in bioimaging and screening for anticancer agents. Park, J.+; Lee, H.-Y.+; Cho, M.-H.; Park, S. B.* Angew. Chem. Int. Ed. 2007, 46, 2018–2022. (+ : both authors equally contribute in this work) (IF: 12.735)
(25) Novel Application of Leuckart-Wallach Reaction for Synthesis of Tetrahydro-1,4-benzodiazepin-5-ones Library. Lee, S. -C.; Park, S.B.* Chem. Commun. 2007,3714–3716. (IF: 5.787)
(24) Enhanced Efficacy of 7-hydroxy-3-methoxycadalene via glycosylation in in vivo xenograft study. Lee, H. Y.; Kwon, J.-T.; Koh, M.; Cho, M.-H.*; Park, S.B.* Bioorg. Med. Chem. Lett. 2007, 17, 6335–6339. (IF: 2.538)
(23) A practical procedure for producing silver nanocoated fabric and its antibacterial evaluation for biomedical application. Lee, H. Y.; Park, H. K.; Lee, Y. M.; Kim, K.*; Park, S.B.* Chem. Commun. 2007,2959–2961. (IF: 5.787)
(22) Practical Solid-Phase Parallel Synthesis of 5-2-oxopiperazines via N-acyliminium Ion Cyclization. Lee, S. -C.; Park, S.B.* J. Comb. Chem. 2007, 9, 828–835. (IF: 3.459)
(21) Synthesis and in vitro phtodynamic activities of water-soluble fluorinated tetrapyridylporphyrins as tumor phtosensitizers. Ko, Y.-J.; Park, J.; Kang, M.-S.; Yun, K.-J.; Lee, J.-T.; Park, S.B.*; Shin, J.-H.* Bioorg. Med. Chem. Lett. 2007, 17, 2789–2794. (IF: 2.538)
(20) Polo-like kinase 2 (PLK2) gene expression is regulated by the orphan nuclear receptor estrogen receptor-related receptor (ERR) gamma. Park, Y.-Y.; Kim, S.-H.; Kim, Y.J.; Kim, S.Y. Lee, T.-H.; Lee, I.-K.; Park, S.B.; Choi, H.-S.* Biochem. Biophy. Res. Commun. 2007, 362, 107–113 (IF: 2.855)
2006
(19) Preparation of Pilot Library with Tetrahydro-β-Carboline Alkaloid Core Skeleton using Tandem Intramolecular Pictet-Spengler Cyclization. Lee, S.-C.; Choi, S.Y.; Chung, Y.K.; Park, S.B.* Tetrahedron Letters 2006, 47, 6843–6847 (IF: 2.509)
(18) Abc Amino Acids: Design, Synthesis, and Properties of New Photoelastic Amino Acids. Standaert, R.F.*; Park, S.B.* J. Org. Chem. 2006, 71, 7952–7966 (IF: 3.790)
(17) Concise and Diversity-Oriented Synthesis of Novel Scaffolds Embedded with Privileged Benzopyran Motif Ko, S. K.; Jang, H. J.; Kim, E.; Park, S.B.* Chem. Commun. 2006, 28, 2962–2964 (IF: 5.787)
(16) A Robust Small-Molecule Microarray Platform for Screening Cell Lysates Bradner, J. E.; McPherson, O.M.; Mazitschek, R.; Barnes-Seeman, D.; Shen, J.P.; Dhaliwal, J.; Stevenson, K.E.; Duffner, J.L.; Park, S.B.; Neuberg, D.S.; Nghiem, P.; Schreiber, S.L.; Koehler, A.N.* Chem. Biol.2006, 13, 493–504. (IF: 6.677)
(15) Quantitative Evaluation of HiCore Resin for the Nonspecific Binding of Proteins by On-bead Colorimetric Assay Kim, D.; Lee, H.Y.; Kim, H.; Kim, H. Lee, Y.-S.*; Park, S. B.* J. Comb. Chem. 2006, 8, 280–285. (IF: 3.459)
(14) Specific targeting, cell sorting and bio-imaging with smart magnetic core-silica shell nanomaterials Yoon, T.-J.; Yu, K.N.; Kim, E.; Kim, J.S.; Kim, B.G.; Yun, S.-H.;Sohn, B.-H.; Cho, M.-H.; Lee, J.-K.*; Park, S.B.* Small 2006, 2, 209–215. (IF: 6.024)
(13) Cellular uptake of magnetic nanoparticle is mediated through energy-dependent endocytosis in A549 Cells, Kim, J.S.; Yoon, T.-J.; Yu, K.-N.; Kim, B.-G.; Sohn, B.-H.; Park, S.B.; Lee, J.-K.; Cho, M.-H.* J. Vet. Sci. 2006, 7(4), 321–326. (IF: 2.112)
(12) Toxicity and Tissue Distribution of Magnetic Nanoparticles in Mice, Kim, J. S.; Yoon, T.-J.; Yu, K.-N.; Kim, B.-G.; Park, S.-J.; Kim, H.W.; Lee. K.H.; Park, S.B.; Lee, J.-K.*, Cho. M.-H.* Toxicological Sciences 2006, 89, 338–347. (IF: 3.088)
(11) Solid-Phase Parallel Synthesis of Natural Product-like Diaza-Bridged Heterocycles through Pictet-Spengler Intramolecular Cyclization. Lee, S.-C.; Park, S.B.* J. Comb. Chem. 2006, 5, 50–57. (IF: 3.459)
2005
(10) Crystallization and preliminary X-ray diffraction analysis of importin acomplexed with NLS peptidomimetics Fontes, M.R.M.; Teh, T.; Riell, R.D.; Park, S.B.; Standaert, R.F.; Kobe, B. Biochemica et Biophysica Acta 2005, 1750, 9–13 (IF: 2.980)
(9) Exploration of Biological Systems using bioactive small molecules Park, S.B.* Chemworld, 2005, 4, 30–37 (Review in Korean)
~ Before 2005
(8) Simple Mimetics of a Nuclear Localization Signal (NLS) Park, S.B.; Ho, T.H.; Reedy, B.M.; Connolly, M.D.; Standaert, R.F.* Organic Letter 2003, 5, 2437–2440
(7) Expanding the Functional Group Compatibility of Small Molecule Microarrays: Discovery of Novel Calmodulin Ligands Barnes-Seeman, D.; Park, S.B.; Koehler, A.N.; Schreiber, S.L.* Angew. Chem. Int. Ed. 2003, 42, 2376–2379; Angew. Chem. 2003, 115, 2478–2481 (with cover image of Angewandte Chemie)
(6) Skeletal Diversity via a Branched Pathway: Efficient Synthesis of 29,400 Discrete, Polycyclic Compounds and Their Arraying into Stock Solutions. Kwon, O.;Park, S.B.; Schreiber, S.L.* J. Am. Chem. Soc. 2002, 124, 13402–13404.
(4) A photo-regulated ligand for the nuclear import receptor karyopherin a. Park, S.B.; Standaert, R.F.* Bioorg. Med. Chem. 2001, 9, 3215–3223
(3) A simple, solid-phase binding assay for the nuclear import receptor karyopherin a. Part II: Competitive Binding. Park, S.B.; Reedy, B.M.; Standaert, R.F.* Bioorg. Med. Chem. Lett. 2000, 10, 955–956
(2) A simple, solid-phase binding assay for the nuclear import receptor karyopherin a. Part I: Direct Binding. Connolly, M.D.; Park, S.B.; Reedy, B.M.; Standaert, R.F.* Bioorg. Med. Chem. Lett. 2000, 10, 951–954
(1) a,a-Difluorophosphonomethyl Azobenzene Derivatives as Photoregulated Phosphoamino Acid Analogs. 1. Design and Synthesis. Park, S.B.; Standaert, R.F.* Tetrahedron Lett. 1999, 40, 6557–6560