Diversity-oriented Organic Synthesis (DOS)

Development of new reaction pathway to access natural-product-like complex small molecules
Cheminformatics approach for intelligently designed small molecule library to maximize the diversity
Library realization for biological evaluation

 

High Throughput Screening (HTS)

Reverse Chemical Genetics using small molecule microarray screening (Chemical chip approach)
Protein-small molecule affinity study using Surface Plasmon Resonance (Biacore approach)
Forward Chemical Genetics using cell- or enzyme-based fuctional assay (Microtiter-plate approach)
Tracking down the biological targets for bioactive small molecules

 

Chemical Biology

The alternation of protein function using bioactive small molecule to emulate or study biological system
Development of new therapeutic agents or biological tools
Development of protein heterodimerizer using small molecules to pertub their functions
Development of non-peptidic NES for the control of protein shuttling between necleus and cytoplasm

 

ETC.